VirtualBox is a community effort backed by a dedicated company: everyone is encouraged to contribute while Oracle ensures the product always meets professional quality criteria. ![]() VirtualBox is being actively developed with frequent releases and has an ever growing list of features, supported guest operating systems and platforms it runs on. Presently, VirtualBox runs on Windows, Linux, macOS, and Solaris hosts and supports a large number of guest operating systems including but not limited to Windows (NT 4.0, 2000, XP, Server 2003, Vista, Windows 7, Windows 8, Windows 10), DOS/Windows 3.x, Linux (2.4, 2.6, 3.x and 4.x), Solaris and OpenSolaris, OS/2, and OpenBSD. See " About VirtualBox" for an introduction. Not only is VirtualBox an extremely feature rich, high performance product for enterprise customers, it is also the only professional solution that is freely available as Open Source Software under the terms of the GNU General Public License (GPL) version 3. VirtualBox is a powerful x86 and AMD64/Intel64 virtualization product for enterprise as well as home use. VM VirtualBox, its high performance, cross-platform virtualization software. Oracle today released a significant new version of Oracle Oracle today released a 6.1 maintenance release which improves stability and fixes regressions. It does not store any personal data.Oracle today released a 7.0 maintenance release which improves stability and fixes regressions. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. You can work in the virtual machine as if it is an another PC.
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11/5/2023 0 Comments French keyboard layout macbook pro![]() Show Emoji & Symbols: Opens the Character Viewer for entering emoji, symbols, and more. If your Mac has a backlit keyboard, choose how long your Mac is idle before the keyboard backlighting is automatically turned off.Ĭhoose what happens when you press the key on the keyboard:Ĭhange Input Source: Switches between keyboard layouts for writing in other languages (known as input sources). Turn keyboard backlight off after inactivity ![]() See Turn your Mac keyboard’s backlighting on or off. If your Mac has a backlit keyboard, automatically adjust the level of backlighting in low-light conditions. Set how quickly characters repeat when you press and hold certain keyboard keys, and how long to wait before repeating them. Get started with accessibility features.Use Sign in with Apple for apps and websites.Watch and listen together with SharePlay.Share and collaborate on files and folders.Sync music, books, and more between devices.Make and receive phone calls on your Mac.Use one keyboard and mouse to control Mac and iPad.Use Live Text to interact with text in a photo.Make text and other items on the screen bigger. ![]() Install and reinstall apps from the App Store.territories, please call Goldman Sachs at 87 with questions about Apple Card. Apple Card is subject to credit approval, available only for qualifying applicants in the United States, and issued by Goldman Sachs Bank USA, Salt Lake City Branch. To access and use all Apple Card features and products available only to Apple Card users, you must add Apple Card to Wallet on an iPhone or iPad that supports and has the latest version of iOS or iPadOS. See (Opens in a new window) for information about upcoming changes to ACMI financing. ACMI financing is subject to change at any time for any reason, including but not limited to, installment term lengths and eligible products. The last month’s payment for each product will be the product's purchase price, less all other payments at the monthly payment amount. ![]() ACMI is not available for purchases made online at special storefronts. See the Apple Card Customer Agreement (Opens in a new window) for more information. Taxes and shipping are not included in ACMI and are subject to your card’s variable APR. * Monthly pricing is available when you select Apple Card Monthly Installments (ACMI) as payment type at checkout at Apple, and is subject to credit approval and credit limit. See the Apple Card Customer Agreement (Opens in a new window) for more information about ACMI financing. ACMI is not available for purchases made online at the following special stores: Apple Employee Purchase Plan participating corporate Employee Purchase Programs Apple at Work for small businesses Government, and Veterans and Military Purchase Programs, or on refurbished devices. An iPhone purchased with ACMI is always unlocked, so you can switch carriers at any time. You’ll need to select AT&T, T-Mobile, or Verizon as your carrier when you check out. Taxes and shipping on ACMI purchases are subject to the variable APR, not 0% APR. If you buy an ACMI eligible product by choosing to pay in full with Apple Card (instead of using ACMI), that purchase is subject to the Apple Card variable APR, not 0% APR. Existing cardholders: see your Customer Agreement for applicable rates and fee. Cardholders who accept an Apple Card on and/or after August 10, 2023: variable APRs for Apple Card, other than ACMI, range from 19.24% to 29.49% based on creditworthiness. APR ranges may vary based on when you accepted an Apple Card. See (Opens in a new window) for more information about eligible products. for eligible Apple products purchased at Apple Store locations, (Opens in a new window), the Apple Store app, or by calling 1-800-MY-APPLE, and is subject to credit approval and credit limit. ◊ Apple Card Monthly Installments (ACMI) is a 0% APR payment option that is only available if you select it at checkout in the U.S. 11/5/2023 0 Comments Phoenix amazon drone delivery![]() The drone can only carry a certain size of box and it dumps packages from 12 feet in the air, further limiting the types of products it can transport. One other aspect that doesn't help Amazon's prospects is that folks who want to receive deliveries by drone need a backyard where packages can be dropped off - so apartment dwellers need not apply. The agency has given Wing, Flytrex and Zipline permission to fly over roadways - to date, Wing has carried out more than 300,000 deliveries. The report suggests the drone's mass could be causing concern among FAA officials. Amazon's drone, on the other hand, weighs around 80 pounds and can only carry a five-pound payload. That depot is on an industrial block, and the drones need to fly over at least one road before getting to any homes.Īmazon's drones are far heavier than ones operated by Wing, as well as Walmart’s partners Flytrex and Zipline. One of the plans the FAA agreed to, according to the report, was for Amazon employees to check no cars were passing on surrounding roads before drones left its Lockeford delivery facility. It has largely rejected Amazon's requests to loosen the limitations. Although Amazon had touted its FAA certification, the agency imposed a string of restrictions, which hadn't been revealed until now. The report suggests that Amazon has been hamstrung by the Federal Aviation Administration, which is said to be blocking drones from flying over roads or people unless the company gets permission on a case-by-case basis. ![]() Given the multiple signaling-driven features, treatment of TPBC with multi-targeted agents may block the complex network more effectively. However, the curative efficacy of this combinatory regimen remains unsatisfactory. In the TBCRC 023 study, patients with ER-positive, HER2-positive breast cancer receiving 12-week or 24-week treatment had a bpCR of 9% or 33% with minimal side effects 9. In the TBCRC 006 study, the pCR rate of neoadjuvant lapatinib and trastuzumab plus letrozole was 18% in patients with ER-positive, HER2-positive breast cancer 8. Clinical trials have shown that the combination of HER2-targeted therapy with endocrine therapy achieved a moderate therapeutic efficacy in HR-positive, HER2-positive breast cancer 8, 9. However, few studies have focused on the treatment exploration for TPBC in the neoadjuvant setting.Īmple evidence has unveiled that complex crosstalk between HER2 and ER signaling lays the foundation for poor response to current therapies in patients with TPBC and for a rationale to block them simultaneously 6, 7. A retrospective study reported that neoadjuvant chemotherapy combined with trastuzumab treatment only resulted in a pathological complete response (pCR) rate of 20% in patients with TPBC, the lowest among all subgroups of HER2-positive breast cancers 5, indicating that optimized therapeutic strategies are urgently required for the management of TPBC. TPBC displays unique biological behaviors and manifests a poorer response to standard neoadjuvant therapy than hormone receptor (HR)-negative, HER2-positive breast cancer 3, 4. More than 50% of HER2-positive breast cancers express intact estrogen receptor (ER) and progesterone receptor (PR), termed triple-positive breast cancer (TPBC) 2. Human epidermal growth factor receptor 2 (HER2) overexpression is found in approximately 15–20% of breast cancer patients with an aggressive phenotype and detrimental outcome 1. This fully oral, chemotherapy-free, triplet combined therapy has the potential to be an alternative neoadjuvant regimen for patients with TPBC. There is no serious adverse event- or treatment-related death. The most frequent grade 3 or 4 adverse events are neutropenia, leukopenia, and diarrhoea. ![]() The mean Ki67 expression reduces from 40.4% at baseline to 17.9% ( P < 0.001) at time of surgery. Following 5 cycles of 4-week treatment, the results meet the primary endpoint with a pCR rate of 30.4% (24 of 79 95% confidence interval (CI), 21.3–41.3). The secondary endpoints include residual cancer burden (RCB)−0 or RCB-I, objective response rate (ORR), breast pCR (bpCR), safety and changes in molecular targets (Ki67) from baseline to surgery. The primary endpoint is the proportion of patients with pathological complete response (pCR) in the breast and axilla. We conduct a multi-center single-arm phase 2 trial to test the efficacy and safety of an oral neoadjuvant therapy with pyrotinib, letrozole and dalpiciclib (a CDK4/6 inhibitor) in patients with treatment-naïve, stage II–III TPBC with a Karnofsky score of ≥70 (NCT04486911). Nature Communications volume 13, Article number: 7043 ( 2022)Ĭurrent therapies for HER2-positive breast cancer have limited efficacy in patients with triple-positive breast cancer (TPBC). A multicentre single arm phase 2 trial of neoadjuvant pyrotinib and letrozole plus dalpiciclib for triple-positive breast cancer 11/5/2023 0 Comments Nude yulia nova![]() ![]() Yulia Nova has an average Hotness Rating of 9.56/10 (calculated using top 20 Yulia Nova naked. It was reported that she has retired from modelling, has had a breast reduction and is now married. Yulia Nova Nude Pictures, Videos, Biography, Links and More. Tranny with massive dick impresses blonde chick: Amicable Exes - Yulia Masakowa 3. Yulia says she wishes to remain "unknown" within Russia. Hardcore Bisexual Pick Ups vol2 Ella Nova, Nikki Darling, Denali Winter. Numerous DVDs and other physical products of her work are available worldwide. Yulia has appeared repeatedly in Japan's Bachelor magazine, an erotica publication that specializes in mostly European women with very large breasts. Because of Japanese censorship laws, all photographs and videos of Yulia obscure her pubic area at least partly, by black bars over her genitals in photos that would otherwise be revealing and by pixelization in videos when she is in revealing positions. Yulia’s publicly released work has been softcore in content, with no sexual activity or explicit display of genitalia. In 2003, the copyright holder for these photographs successfully lobbied the Google search engine to block websites containing unauthorized copies of the photographs. However, her photographs and videos are also available widely from various Internet sources, giving her worldwide recognition. To date, she has appeared in seven VHS tapes, eleven DVDs, three photobooks, and numerous magazines for the Japanese market. Her first three videos were made near Christmas 2000, at age 18. She was chosen over one hundred other applicants that fall. Yulia Nova is a university law student who entered a "Russian Beauties Contest" sponsored by photographer Satoshi Kizu in the summer of 2000. 5 If you like Yulia Nova, you might also like.Yulia Nova - RBD-25 Natural Breasts Russian Yulia Nova 2 h 2 min 360p Natasha ( Yulia Nova ) Brunette Big Tits Russian Teen p beautiful teen Russian big tits 3 Tits Big 10 min 360p Yulia Nova - Summer Memory Part 2 Russian Natural Tits Big Tits 1 h 27 min 360p backstaeg5 Lesbians Bigtits Brunette 5 min 360p Perfect huge boobs Boobs Tits Stripping 2 min 360p Ewa Sonnet Big Tits Walking European Tits 1 min 720p Yulia Nova - Summer Memory Part 3 Big Tits Yulia Nova Huge Boobs 1 h 29 min 360p Very Hot Big Natural Tits Blonde Teen Sex Cams Camgirl Home Video 3 min 720p - 100 Big Know Who 10 min 360p Yulia Nova - A tribute to big boobs Sensual Lingerie Huge Boobs 3 min 720p Olga ( Claudia ), Natasha ( Yulia Nova ), Alena ( Klarissa ) & Nikita Big Tits Russian Olga 30 min 360p Celebrity Hairy Pussy Compilation (with Names) Celebrity Babes Pussy 6 min 720p and shower anal fantasy And Shower Step Sister 16 min 360p The most beautifull woman Asain Asians Asian Woman 1 min 360p beautiful teen Russian big tits Tits Big 24 min 360p Sha Rizel seducion Erotico Solo Tetonas 21 min 360p beautiful Russian teen big tits 2 Tits Big 27 min 360p Webcam 5 - can be found at SweetCams.TV Webcam Sexy Reality 3 min 360p Three girls with perfect natural tits Tits Girls Solo 5 min 720p Yulia - una Tetona Increíble - Yulia Tetona 4 min 360p Sexy teen with big tits takes a hot shower - watch more at Butt 18 Boobs 2 min 360p peituda tomando banho Banho Peituda Gostosa 17 min 720p Slut Brunette Show Her Big Tits - CamWebShows. Yulia Nova (1), Yuu Haruka (10), Zazie Skymm (1), Zoe Voss (1), Zoey Holloway (1), Zo Birdy (1). 11/5/2023 0 Comments Im still here documentary![]() Just lean back, and Susie and I are going to take you. Why am I living?" That is-I think about that constantly. My name is Tawnni Simpson I'm 25 and I think about "Why the hell me? Why do I have cystic fibrosis, but not only why do I have cystic fibrosis-why am I still living and all my friends that I grew up with, with cystic fibrosis and been in and out of the hospital with, are all dead. Their gestures and stories became the inspiration for "Still/Here" and a demonstration of the healing power of art. Nearly 100 people volunteered to talk and perform for Jones' cameras. I fear that my struggle to survive will be too painful. My name is Jay, and I love to make others smile. And the things that I fear are plane crashes. My name is Val, and the things that I love my husband, my children. Jones asked them to tell him what they loved, what they feared, what they wanted. Jason, Arnie, Val, Susie, Edie, Andrea, Louanna. ![]() reaching out to men and women who had never danced before. ![]() The words we hear, many of the movements we see, come directly from people facing sickness and death.įor over a year, Jones traveled the country -to Milwaukee, Austin, Pittsburgh. The creation of "Still Here" is the story of an extraordinary collaboration. But what makes "Still/Here" so powerful goes beyond the dance itself. Critics will call this his most important work, a landmark of 20th century dance. "Still/Here" will go on to critical and audience acclaim. I wish I was out there with you, but you know, I don't. Tonight is the American premier of his most ambitious dance yet - Still/Here. JONES:, this is the exciting and climactic moment. Just the sort of thing before a performance, huh?īILL T. That's the best cooked roast beef I've ever seen. Can I have just a little bit of a downstage cut, off the How could you conceptualize your lives if you draw it as a line? But sometimes I'm ready to go, like an angel. And I'm going to take it, I'm going to make it song, I'm going to make it movement. What do you know? What do you know that I don't know? What do you-what do we have in common that the average person does not? Tell me it. I said "Let's go out and deal with the people who know-who are front-line. įor me, as a person who has to deal with his own possible early death, is looking at people who are dealing with the same thing. These are all just places, but there's no reason you couldn't - they couldn't move. Well, my job is to evoke the spirit of survival. When I became sick, the pain overcame me.Īnd I overcame the pain to stand up straight and face the world. What does it look like? What does it feel like, taste like, smell like? The profoundest questions that I can ask can be answered with other people who are not in the dance world -literally, the issue of life and death. Peace I will find.Ĭindy -this is "a bird flying in the breeze." This is me now, remembering what it was like to nurse my little boy when he was a baby. This is me before I was diagnosed with cancer. WORKSHOP PARTICIPANT, Member of group of people, all with terminal illnesses: Grab it up." Bill-"Drink to me only with thine eyes." Devin -"Torn." Don -"Don't tie my hands." Chris -"Reaching up to a higher power, coming up empty-handed, coming back to myself." Bonnie -"Engulfing the whole universe. 11/5/2023 0 Comments Knight of cups trailer![]() ![]() To say that Malick and company are biting off more than they can chew or that they think of these films as more important than they are is a bit insulting to not only the filmmakers but also to those of us with a background in theology, mysticism, and/or the occult. Pretentious is a word that I think most people use to excuse their poor taste and/or lack of comprehension of a given work of art. I'm guessing the hypothesis for "Knight of Cups" was: Can I push the boundaries of visual language farther than the limits of my audience's patience? Given the past several films have continually pissed off Malick fans and haters alike, it is no surprise that you'll hear the word "pretentious" thrown out fairly often. It is an experimental film, and like all experiments it must have a hypothesis. Malick's defining work "The Tree of Life" is an absolute masterpiece of cinema, and this movie seems to be an extension of that. ![]() But if you aren't in the mood, it can be a grating bore. It is a beautiful but somewhat empty gift box that you can place whatever dreams, beliefs, or meaning you want inside. Taking the poetic stylism of his past few films to the absolute extreme, a few lines of on-screen dialogue become vital breaths of fresh air as the viewer wades in the mystifying soundtrack, swims through whispers of narrated subconsciousness, and drowns in the free-flowing dance of the camera. If this is true then Malick has revealed himself to be less of a Bodhisattva and more of a bourgeois savant in "Knight of Cups". If Bale is here representing anything or anyone, most would place their bets on it being director Terrence Malick himself. Christian Bale's character seems to do just that in this film, and it was very difficult to feel any sort of kinship or empathy towards him. boobs), he probably wouldn't be a very good role model. If Siddhartha Gautama lived on the west coast, never attained any sort of enlightenment but feigned his spirituality by reading obscure Gnostic texts and getting tarot readings all the while basking in the superfluous reveries of modern America (i.e. 11/5/2023 0 Comments Mmorpg sherwood dungeon![]() The game includes core features, such as Four-playable Characters, Linear MMORPG, Combat, Auto-play System, Real-time Combat, and much more. Escape to a fantasy world that brings together an online community of like-minded players from around the world. Overall, Sherwood Dungeon is a traditional MMORPG -with visuals that fit the premise perfectly- that brings an old school game experience to Android devices. Sherwood Dungeon is a Wonderful, Adventure, Massively Multiplayer Online, Role-playing, Fantasy, and Browser-based video game developed and published by Maid Marian. Download and Play Now Welcome to Sherwood Dungeon, a uniquely indie massive multiplayer online RPG with no registration required. Of course, you'll also earn money as you complete missions that you can invest in all kinds of upgrades and items, including animals you can ride across the map. Similar to other MMORPGs, players begin Sherwood Dungeon by accepting simple missions from other characters, such as killing a certain number of spiders, and progress to more difficult missions as they level up. Finally, you can unlock new skills and attacks as you level up your character. To interact with items or chat with characters, just tap on them. Sherwood Classic was an MMORPG and the predecessor to Sherwood Dungeon, created by Gene Endrody, the founder of Maid Marian Entertainment. Simply use the virtual joystick on the left side of the screen to control your character, and the buttons on the right side of the screen to attack your enemies. Sherwood Dungeon has easy-to-use controls. Start a new game and choose from one of the various character options, including men, women, and skeletons. Sherwood Dungeon is an MMORPG set in a medieval fantasy world that you can freely explore. 11/5/2023 0 Comments Pmi pmp application examples![]() Read more about the Agile software development life cycle in our Agile guide.Īgile methodology in non-software projects Retirement: The end of the product lifespan, which often coincides with the beginning of a new one.Maintenance: Provide ongoing tech support to ensure the product remains serviceable.Release: Test the code and troubleshoot any issues.Iteration: Create code factoring in customer feedback.Inception: Build the Agile team according to project requirements.Concept: Define the project scope and priorities.The Agile software development life cycle helps you break down each project you take on into six simple stages: By listening to customer feedback and carrying out several iterations and rounds of software testing, you can iron out any kinks along the way and build the best possible software. ![]() One of the most compelling reasons to adopt the Agile approach in software development is the dynamic workflows and work systems that contribute to a better end product. By prioritizing flexibility, Agile teams can quickly react to changes, deliver products faster, and thrive in a collaborative environment.īy building Agile teams with the right qualities - such as self-organization and effective collaboration - you can accelerate the software development process while leaving space for vital customer feedback. With an iterative and adaptive approach, the aim is to produce the highest-quality software product that puts the customer at the heart of the process. Through iterations and incremental efforts, they incorporate collaboration and customer feedback, leading to continuous improvement.Īgile enables software development teams to stay adaptable. Every Agile framework emphasizes a degree of adaptability, breaking projects into phases and embracing changing requirements. As a result, Waterfall suits projects with fixed guidelines and minimal changes.īy comparison, Agile methodologies are far more fluid in nature. Changes are difficult to incorporate once a stage is completed and customer interactions are limited. They are required to complete one phase before moving on to the next one. When working with this traditional methodology, teams would follow a strictly linear sequence: requirements gathering, design, build, test, deliver. So, how do these Agile methodologies compare to traditional approaches to project management? Let’s highlight the Waterfall approach as an example. You can learn more about the different types of Agile methodologies in our guide. Lean: It streamlines processes, eliminating waste for customer value.Įxtreme Programming (XP): It enhances software quality and responsiveness to customer satisfaction.Īdaptive Project Framework (APF): Works well for projects with unclear details, as it adapts to constantly evolving client needs. Kanban: It visualizes project progress and is great for tasks requiring steady output. Scrum: It is ideal for projects with rapidly changing requirements, using short sprints. See below an example from Wrike’s Agile project management dashboard from our Agile teamwork template.Īgile project management is not a singular framework but an umbrella term that includes a wide range of methodologies, including Scrum, Kanban, Extreme Programming (XP), and the Adaptive Project Framework (APF). You can read more about the six stages of the Agile life cycle in our Agile guide. Continuous improvement: As an iterative approach, Agile project management allows teams to chip away at tasks until they reach the best end result.Customer and stakeholder alignment: Through focusing on customer concerns and stakeholder feedback, the Agile team is well positioned to produce results that satisfy the right people.Rapid progress: By effectively reducing the time it takes to complete various stages of a project, teams can elicit feedback in real time and produce working prototypes or demos throughout the process.Many teams embrace the Agile approach for the following reasons: What are the benefits of using Agile methodology?Īgile is one of the most popular approaches to project management because it is flexible, it is adaptable to changes and it encourages customer feedback. It works off the basis that a project can be continuously improved upon throughout its life cycle and adapt to changes quickly. Agile project management is a process for managing a project that involves constant collaboration and working in iterations. 11/4/2023 0 Comments Definition of sigma bondA tertiary carbon has three carbon neighbors.A secondary carbon has two carbon neighbors.A primary carbon has one carbon neighbor.Carbon atoms in a molecule are categorized by the number of carbon neighbors they have: This coupled with the strength of the carbon–carbon bond gives rise to an enormous number of molecular forms, many of which are important structural elements of life, so carbon compounds have their own field of study: organic chemistry.īranching is also common in C−C skeletons. Chains and branching Ĭarbon is one of the few elements that can form long chains of its own atoms, a property called catenation. The use of the p-orbitals forms a pi bond. A triple bond is formed with an sp-hybridized orbital and two p-orbitals from each atom. A double bond is formed with an sp 2-hybridized orbital and a p-orbital that is not involved in the hybridization. Carbon atoms can also form double bonds in compounds called alkenes or triple bonds in compounds called alkynes. ![]() In fact, the carbon atoms in the single bond need not be of the same hybridization. In ethane, the orbitals are sp 3- hybridized orbitals, but single bonds formed between carbon atoms with other hybridizations do occur (e.g. ![]() The carbon–carbon single bond is a sigma bond and is formed between one hybridized orbital from each of the carbon atoms. The most common form is the single bond: a bond composed of two electrons, one from each of the two atoms. ![]() A carbon–carbon bond is a covalent bond between two carbon atoms. |
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